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Ro 48-8071 fumarate
CAS No. 189197-69-1
Ro 48-8071 fumarate( Ro-488071 fumarate )
Catalog No. M12966 CAS No. 189197-69-1
A potent 2,3-oxidosqualene cyclase (OSC) inhibitor with IC50 of 6.5 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 41 | In Stock |
|
| 10MG | 61 | In Stock |
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| 25MG | 90 | In Stock |
|
| 50MG | 113 | In Stock |
|
| 100MG | 186 | In Stock |
|
| 200MG | 242 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameRo 48-8071 fumarate
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NoteResearch use only, not for human use.
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Brief DescriptionA potent 2,3-oxidosqualene cyclase (OSC) inhibitor with IC50 of 6.5 nM.
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DescriptionA potent 2,3-oxidosqualene cyclase (OSC) inhibitor with IC50 of 6.5 nM; 6 times less potent against hamster and Gottingen minipig liver OSC, and 10-times more potent against squirrel monkey liver OSC; blocks human liver OSC and cholesterol synthesis in HepG2 cells in the nanomolar range; triggers the production of monooxidosqualene, dioxidosqualene, and epoxycholesterol.Dyslipidemia Preclinical
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In Vitro——
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In Vivo——
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SynonymsRo-488071 fumarate
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PathwayOthers
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TargetOther Targets
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RecptorOxidosqualenecyclase
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Research AreaCardiovascular Disease
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IndicationDyslipidemia
Chemical Information
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CAS Number189197-69-1
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Formula Weight564.4406
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Molecular FormulaC27H31BrFNO6
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 55 mg/mL
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SMILESO=C(C1=CC=C(OCCCCCCN(CC=C)C)C=C1F)C2=CC=C(Br)C=C2.O=C(O)/C=C/C(O)=O
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Chemical NameMethanone, (4-bromophenyl)[2-fluoro-4-[[6-(methyl-2-propen-1-ylamino)hexyl]oxy]phenyl]-, (2E)-2-butenedioate (1:1)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Morand OH, et al. J Lipid Res. 1997 Feb;38(2):373-90.
2. Peffley DM, et al. Biochem Pharmacol. 1998 Aug 15;56(4):439-49.
3. Liang Y, et al. Onco Targets Ther. 2016 May 30;9:3223-32.
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