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Ro 48-8071 fumarate

CAS No. 189197-69-1

Ro 48-8071 fumarate ( Ro-488071 fumarate )

Catalog No. M12966 CAS No. 189197-69-1

A potent 2,3-oxidosqualene cyclase (OSC) inhibitor with IC50 of 6.5 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Ro 48-8071 fumarate
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent 2,3-oxidosqualene cyclase (OSC) inhibitor with IC50 of 6.5 nM.
  • Description
    A potent 2,3-oxidosqualene cyclase (OSC) inhibitor with IC50 of 6.5 nM; 6 times less potent against hamster and Gottingen minipig liver OSC, and 10-times more potent against squirrel monkey liver OSC; blocks human liver OSC and cholesterol synthesis in HepG2 cells in the nanomolar range; triggers the production of monooxidosqualene, dioxidosqualene, and epoxycholesterol.Dyslipidemia Preclinical
  • Synonyms
    Ro-488071 fumarate
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Oxidosqualenecyclase
  • Research Area
    Cardiovascular Disease
  • Indication
    Dyslipidemia

Chemical Information

  • CAS Number
    189197-69-1
  • Formula Weight
    564.44
  • Molecular Formula
    C27H31BrFNO6
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 55 mg/mL
  • SMILES
    O=C(C1=CC=C(OCCCCCCN(CC=C)C)C=C1F)C2=CC=C(Br)C=C2.O=C(O)/C=C/C(O)=O
  • Chemical Name
    Methanone, (4-bromophenyl)[2-fluoro-4-[[6-(methyl-2-propen-1-ylamino)hexyl]oxy]phenyl]-, (2E)-2-butenedioate (1:1)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Morand OH, et al. J Lipid Res. 1997 Feb;38(2):373-90.
2. Peffley DM, et al. Biochem Pharmacol. 1998 Aug 15;56(4):439-49.
3. Liang Y, et al. Onco Targets Ther. 2016 May 30;9:3223-32.
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