Ro 48-8071 fumarate

Research use only, not for human use.

A potent 2,3-oxidosqualene cyclase (OSC) inhibitor with IC50 of 6.5 nM.

A potent 2,3-oxidosqualene cyclase (OSC) inhibitor with IC50 of 6.5 nM; 6 times less potent against hamster and Gottingen minipig liver OSC, and 10-times more potent against squirrel monkey liver OSC; blocks human liver OSC and cholesterol synthesis in HepG2 cells in the nanomolar range; triggers the production of monooxidosqualene, dioxidosqualene, and epoxycholesterol.Dyslipidemia Preclinical

Ro-488071 fumarate

Others

Other Targets

Oxidosqualenecyclase

Cardiovascular Disease

Dyslipidemia

189197-69-1

564.44

C27H31BrFNO6

>98% (HPLC)

DMSO: ≥ 55 mg/mL

O=C(C1=CC=C(OCCCCCCN(CC=C)C)C=C1F)C2=CC=C(Br)C=C2.O=C(O)/C=C/C(O)=O

Methanone, (4-bromophenyl)[2-fluoro-4-[[6-(methyl-2-propen-1-ylamino)hexyl]oxy]phenyl]-, (2E)-2-butenedioate (1:1)

(-20℃)

With Ice Pack

≥ 2 years