Ro 48-8071 fumarate

CAS No. 189197-69-1

Ro 48-8071 fumarate ( Ro-488071 fumarate )

Catalog No. M12966 CAS No. 189197-69-1

A potent 2,3-oxidosqualene cyclase (OSC) inhibitor with IC50 of 6.5 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 41 In Stock
10MG 61 In Stock
25MG 90 In Stock
50MG 113 In Stock
100MG 186 In Stock
200MG 242 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Ro 48-8071 fumarate
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent 2,3-oxidosqualene cyclase (OSC) inhibitor with IC50 of 6.5 nM.
  • Description
    A potent 2,3-oxidosqualene cyclase (OSC) inhibitor with IC50 of 6.5 nM; 6 times less potent against hamster and Gottingen minipig liver OSC, and 10-times more potent against squirrel monkey liver OSC; blocks human liver OSC and cholesterol synthesis in HepG2 cells in the nanomolar range; triggers the production of monooxidosqualene, dioxidosqualene, and epoxycholesterol.Dyslipidemia Preclinical
  • Synonyms
    Ro-488071 fumarate
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Oxidosqualenecyclase
  • Research Area
    Cardiovascular Disease
  • Indication
    Dyslipidemia

Chemical Information

  • CAS Number
    189197-69-1
  • Formula Weight
    564.44
  • Molecular Formula
    C27H31BrFNO6
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 55 mg/mL
  • SMILES
    O=C(C1=CC=C(OCCCCCCN(CC=C)C)C=C1F)C2=CC=C(Br)C=C2.O=C(O)/C=C/C(O)=O
  • Chemical Name
    Methanone, (4-bromophenyl)[2-fluoro-4-[[6-(methyl-2-propen-1-ylamino)hexyl]oxy]phenyl]-, (2E)-2-butenedioate (1:1)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Morand OH, et al. J Lipid Res. 1997 Feb;38(2):373-90.
2. Peffley DM, et al. Biochem Pharmacol. 1998 Aug 15;56(4):439-49.
3. Liang Y, et al. Onco Targets Ther. 2016 May 30;9:3223-32.
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